Santos FC vs São Paulo: Match Prediction , Preview, Lineups, H2h for September 22, 2025

On September 22, 2025, in matchweek 24 of the Brazilian Championship, Santos will take on São Paulo at Vila Belmiro stadium. This rivalry is one of the most intense in Brazil, with both teams hailing from the state of São Paulo, making their matches always highly charged.

See also: Real Madrid vs Espanyol: Madrid aims to keep winning.

Interesting facts and head-to-head history:

• The teams have met 71 times in the Brazilian Serie A.
• This season, Santos has scored over 2.5 goals in 11 out of 19 home games.
• In their last 5 meetings: Santos – 2 wins, draws – 1, São Paulo – 2 wins.
• Santos has won just one of their last 5 matches.
• São Paulo has secured 3 wins in their last 5 matches.

Match preview:

Santos has shown inconsistency this season, alternating between wins and losses, and their pursuit of a top position continues. Their main hope lies in a strong attacking line that can create opportunities.

São Paulo, however, comes into this match as a more stable team. They have experienced players who can influence the game during critical moments. Nevertheless, playing away, especially against a tough rival like Santos, is challenging.

The match is expected to be fierce, with both teams likely giving their all. The crowd is sure to be vibrant, and the outcome remains uncertain.

Probable line-ups:

• Santos: Diogenes, Mayke, Luizão, Peres, Escobar, Rincon, Bontempo, Rolheiser, Barreal, Neymar, Guilherme.
• São Paulo: Rafael, Ferraresi, Franco, Sabino, Soares, Bobadilla, Maia, Rodriguinho, Diaz, Luciano, Tapia.

Santos vs São Paulo match prediction:

Both teams have strong offenses and have frequently exchanged goals in past encounters. Santos tends to play dynamically at home, while São Paulo can take advantage of their opponents’ errors when playing away. The prediction is for both teams to score (Yes).